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CNS-Active N-acyl-asparagyl-glutamic acids and salts - prepd by reacting N-acyl aspartic acid with anhydride, then reaction with glutamic acid salt
CNS-Active N-acyl-asparagyl-glutamic acids and salts - prepd by reacting N-acyl aspartic acid with anhydride, then reaction with glutamic acid salt
N-Acyl(alpha- andd beta-)asparaglyl-glutamic acids and salts in L- or DL-form, are of general formula (I) and (II): (in which M = a cation with n-valency which is either a metal cation of a cation of an organic substance such as amino alcohol, amino acid or a quat. ammonium cpd. e.g., a betaine or choline; R = acyl; m = 0,1,2 or 3 and varies with the number of carboxyl gps. converted to the salt form, whereby m = not 0 when R = acetyl). Specif. cpd. includes Na-salt of N-acetyl-asparagyl-glutamic acid and the K-salt of N-propionyl-asparagyl-glutamic acid both as alpha- and/or beta-isomers in L- or DL-configuration). (I) and (II) allow the introduction of an asparagyl-glutamic acid peptide into the animal and human organism. The salts increase the activity and have selective CNS-activity. They may be used in the treatment of cerebral tiredness, conditions of shock, weakness and depression, loss of memory, etc. They also have cardiovascular activity.
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机译：L-或DL形式的N-酰基（α-和β-）天冬酰胺基谷氨酸及其盐具有通式（I）和（II）：（其中M =具有n价的阳离子有机物质（如氨基醇，氨基酸或季铵基cpd，例如甜菜碱或胆碱）的阳离子的金属阳离子; R =酰基; m = 0,1,2或3，并随羧基转化为盐形式，其中当R =乙酰基时，m =不为0。规格。 cpd。包括N-乙酰基-天冬酰胺基-谷氨酸的Na-盐和N-丙酰-天冬酰胺基-谷氨酸的K-盐，均为L-或DL-构型的α-和/或β-异构体。 （I）和（II）允许将天冬酰胺基谷氨酸肽引入动物和人类有机体。盐增加了活性并具有选择性的CNS活性。它们可用于治疗脑疲劳，休克，虚弱和沮丧，记忆力减退等。它们还具有心血管活性。
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