• 主题
高级搜索  >
历史搜索 清空历史
首页> 外国专利> (DELTA) (UP ARROW) 9 (UP ARROW) (UP ARROW) ((UP ARROW) (UP ARROW) 1 (UP ARROW) (UP ARROW) 1 (UP ARROW) (UP ARROW)) (UP ARROW) - AND (DELTA) (UP ARROW) 1 (UP ARROW) (UP ARROW) 6 (UP ARROW) -21-CHLORINE-20-KETO STEROIDS OF THE PREGNAN AND D-HOMO-PREGNAN SERIES, METHODS FOR THEIR PREPARATION AND USE AS AN INTERMEDIATE PRODUCT FOR THE SYNTHESIS OF HIGHLY EFFECTIVE CORTICOIDS

(DELTA) (UP ARROW) 9 (UP ARROW) (UP ARROW) ((UP ARROW) (UP ARROW) 1 (UP ARROW) (UP ARROW) 1 (UP ARROW) (UP ARROW)) (UP ARROW) - AND (DELTA) (UP ARROW) 1 (UP ARROW) (UP ARROW) 6 (UP ARROW) -21-CHLORINE-20-KETO STEROIDS OF THE PREGNAN AND D-HOMO-PREGNAN SERIES, METHODS FOR THEIR PREPARATION AND USE AS AN INTERMEDIATE PRODUCT FOR THE SYNTHESIS OF HIGHLY EFFECTIVE CORTICOIDS

机译：Δ（向上箭头）9（向上箭头）（向上箭头）（（向上箭头）（向上箭头）1（向上箭头）（向上箭头）1（向上箭头）（向上箭头））（向上箭头）-和PREGNAN和D-HOMO-PREGNAN系列的δ-氯-酮20-酮酮δ-（向上箭头）1（向上箭头）（向上箭头），其制备方法和用作中间体合成高效糖皮质激素的产品

页面导航
  • 摘要
  • 著录项
  • 相似文献

摘要

DELTA 16 and DELTA 17-21-chloro-20-keto steroids of the formula CHEM wherein n is 1 or 2, C1@C2 and C9@C11 represents a CC-single or CC-double bond, R1 is H or OH, R2 is H or CH3, R3 is H or F wherein, when R3 = F, C9@C11 is a CC-single bond, and R4 is H, CH3, or F, are valuable intermediates for preparation of highly effective, known steroids. A process for preparing these compounds involves heating the corresponding 11 beta - and/or 17 alpha - or l7a alpha -nitrooxy-21-mesyloxy-20-keto steroids with lithium chloride in a dipolar aprotic solvent at temperatures above room temperature.
机译：式的DELTA <1> <6>和DELTA <1> <7> -21-氯-20-酮类固醇，其中n为1或2，C1 @ C2和C9 @ C11表示CC单价或CC-双键，R1为H或OH，R2为H或CH3，R3为H或F，其中，当R3 = F时，C9 @ C11为CC单键，R4为H，CH3或F制备高效，已知类固醇的有价值的中间体。制备这些化合物的方法包括在高于室温的温度下，在双极非质子溶剂中用氯化锂加热相应的11β-和/或17α-或17α-α-硝基氧基-21-甲磺酰氧基-20-酮类固醇。

著录项

相似文献

  • 专利
  • 外文文献
  • 中文文献
获取专利

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号