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anti:helminth contg. aryloxy-acetyl-benzimidazole deriv. - for domestic animals and of low toxicity
anti:helminth contg. aryloxy-acetyl-benzimidazole deriv. - for domestic animals and of low toxicity
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机译：反：蠕虫病毒侵害。芳氧基-乙酰基-苯并咪唑衍生物。 -用于家畜和低毒
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摘要
An antihelminthic agent contains, as active ingredient, an aryloxy acetyl benzimidazole deriv. of formula (I), or its (where R1 is alkyl, allyl or propargyl; R2 is u-3C alkylene or -NH-CO-R4; R4 is 1-3C alkylene; Z and R3 are H, halogen, alkyl, alkoxy or nitro; m is 1-4, n is 1-5, X is either not present in an (in)organic acid). The agent canbbe used to treat helminthic disease cattle, sheep, goats, pigs, horses, poultry, dogs, hunting and laboratory animals. (I) are of low toxicity LD50 = 4.8-9.9 g/kg body wt. Suitable doses are 0.05-0.5 g/kg p.o. The cpds. have a low comutation coefficient and the animals do not become accustomed to them. (I) are not allergic or teratogenic and in therapeutic doeses have no effect on the antitoxic function of the liver. (I) also inhibit the toxic effect of CNS stimulators of caffein corasol and strychnine and prolong the effect of depressives, of chloral hydrate and hexenal.
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机译：抗蠕虫药含有作为活性成分的芳氧基乙酰基苯并咪唑衍生物。 （R1为烷基，烯丙基或炔丙基; R2为u-3C亚烷基或-NH-CO-R4; R4为1-3C亚烷基; Z和R3为H，卤素，烷基，烷氧基或硝基; m为1-4，n为1-5，X不在有机酸中。该药剂可用于治疗蠕虫病，包括牛，绵羊，山羊，猪，马，家禽，狗，狩猎和实验动物。 （I）低毒LD50 = 4.8-9.9 g / kg体重合适的剂量是0.05-0.5 g / kg p.o. cpds。折算系数低，动物不习惯它们。 （I）不是过敏性或致畸性的，并且在治疗中对肝脏的抗毒性功能没有影响。 （I）还抑制咖啡因，溶胶，士丁宁的中枢神经系统刺激剂的毒性作用，并延长抑郁症，水合氯醛和己烯醛的作用。
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