3 A - hydroxy - 5b - cholesterol - 24 - ene, this in 3 a of that - ci and their method of preparation

• 1. 高效立体选择性一步还原甾体骨架中的4-烯-3-酮为3a-羟基-5b-氢A/B顺式结构的方法 [P] . 中国专利： CN104059118A . 2014-09-24
• 2. 24-羟基胆固醇在制备诊断或早期诊断精神分裂症的产品中的用途 [P] . 中国专利： CN110646626A . 2020-01-03
• 3. 3 A - hydroxy - 5b - cholesterol - 24 - ene, this in 3 a of that - ci and their method of preparation [P] . 法国专利： FR2373563A1 . 1978-07-07

  机译： 3 A-羟基-5b-胆固醇-24-烯，3 a-ci中的此及其制备方法

• 4. AN IMPROVED METHOD FOR THE PREPARATION OF IR CIS,2,2-DIMETHYL-3-(2-HYDROXY-2-CARBOXYPROPYL)CYCLOPROPANE CARBOXYLIC ACID FROM CAR-4-ENE-3-OL [P] . IN154665B . 1984-12-01

  机译： 由CAR-4-ENE-3-OL制备IR CIS，2,2-二甲基-3-（2-羟基-2-羧丙基）环丙烷羧酸的改进方法

• 5. 24 - separation method null of 24 rank epimer of hydroxy cholesterol [P] . 日本专利： JP2986592B2 . 1999-12-06

  机译： 24-羟基胆固醇24位差向异构体的分离方法无效

• 1. Synthesis and Bioactivity of Isosteviol Derivatives: A Facile Method for Preparation of Ent-16α-hydroxy-15β-hydroxymethylbeyeran-19-oic Acid [J] . Jing Chao TAO, Guo Qiang TIAN, Yan Bing ZHANG, 中国化学快报（英文版） . 2005,第011期
• 2. A New Preparation Method of Sodium Aluminum Hydroxy Carbonate and Potassium Aluminum Hydroxy Carbonate from Basic Aluminum Sulfate [C] . C. A. Contreras, J. I. Macias, E. Ramos Materials Research Society Symposium . 2010
• 3. Studies of reductive lithiation methods for the preparation of organolithium compounds and applications of the palladium catalyzed zinc-ene cyclization. [D] . Yang, Ao. 2007
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• 5. On the Preparation of Cholesterol Labelled with Tritium at Carbon Atoms 24 and 25 (Cholesterol-24,25-T2). Bile Acids and Steroids 54. [O] . S. Bergström, S. Lindstedt, D. Sen, 1957
• 6. Composite Materials with Improved Properties in Compression. Appendix 1.Cyclopropanation of Poly(1-Methyl-1-phenyl-1-sila-cis-pent-3-ene). Synthesis and Characterization of Poly(1-Methyl-3,4-methylene-1-phenyl-1-sila-cis-pent-3-ene) [R] . Liao, X., Lee, H. S., Weber, W. P. 1990

• 1. Development of Preparation Method for Microencapsulating Uycalyptus Oil Containing Fine Aqueous Droplets by Use of Interfacial Condensation Reaction between Hydroxy Propyl Methyl Cellulose and Tannic Acid [J] . Hiroyuki Sato ,Yoshinari Taguchi ,Masato Tanaka . 化妆品、皮肤病及应用期刊（英文） . 2014,第4期
• 2. STRUCTURE OF MOLECULAR COMPOUND CRYSTAL A_2B(A =1, 6, 7, 8,-TETRA-PHENYL (3, 4-BENZO)BICYCLO4, 2, 0OCTA-7-ENE, B=CIS, CIS-1,2,3,4,-TETRAPHENYLBUTADIENE) [J] . 环振威 ,刘卫国 ,等 . 结构化学 . 1993,第5期
• 3. BACKGROUND： Vibrio vulnifi cus inside the body could activate the NF-!B signaling pathwayand initiate the inflammatory cascade. The lung is one of the earliest organs affected by sepsisassociated with acute lung injury. High mobility group protein B1 （HMGB1） is an important late-actingpro-infl ammatory cytokine involving in the pathophysiology of sepsis. It is also involved in the injuryprocess in the lung, liver and intestine. There has been no report on the involvement of HMGB1 inVibrio vulnifi cus sepsis-induced lung injury.METHODS： Sixty rats were randomly divided into a normal control group （group A, n=10） anda Vibrio vulnificus sepsis group （group B, n=50）. Sepsis was induced in the rats by subcutaneousinjection of Vibrio vulnificus （concentration 6×108 cfu/mL, volume 0.1 mL/100g）） into the left lowerlimbs. The rats in group B were sacrifi ced separately 1, 6, 12, 24, and 48 hours after the infection.Their lungs were stored as specimens, lung water content was measured, and lung pathology wasobserved under a light microscope. The expressions of the HMGB1 gene and protein in the lungswere detected by RT-PCR and Western blot. Data were analyzed with one-way analysis of variance（ANOVA） and the LSD method for pair-wise comparison between the two groups. P〈0.05 wasconsidered statistically signifi cant.RESULTS： Compared to group A （0.652±0.177）, HMGB1 mRNA expression in the lungs ofgroup B was signifi cantly higher at 0 hour （1.161±0.358, P=0.013）, 24 hours （1.679±0.235, P=0.000）,and 48 hours （1.258±0.274, P=0.004） （P〈0.05）, and peaked at 24 hours. Compared to group A（0.594±0.190）, HMGB1 protein expression at 6 hours （1.408±0.567, P=0.026） after infection wassignificantly increased （P〈0. 05）, and peaked at 24 hours （2.415±1.064, P=0.000） after infection.Compared to group A （0.699±0.054）, lung water content was significantly increased at 6 hours（0.759±0.030, P=0.001）,12 hours （0.767±0.023, P=0.000）, 24 hours （0.771±0.043, P=0.000） and 48hours （0.789±0.137, P=0.000） after infection （P〈0.05）. Compared to group A, pathological changesat 12 hours in group B indicate marked pulmonary vascular congestion, interstitial edema andinfl ammatory infi ltration. Alveolar cavity collapse and boundaries of the alveolar septum could not beclearly identifi ed.CONCLUSION： Vibrio vulnifi cus sepsis can lead to injury in rat lungs, and increased HMGB1expression in lung tissue may be one of the mechanisms for injury from Vibrio vulnifi cus sepsis. [J] . Qiao-meng Qiu ,Zhong-wang Li ,Lu-ming Tang . 世界急诊医学杂志(英文) . 2011,第4期
• 4. Derivative Spectrophotometric and Isocratic High Performance Liquid Chromatographic Methods for Simultaneous Determination of Repaglinide and Metformin Hydrochloride in Pharmaceutical Preparations [J] . Serap Saglik Aslan ,Berna Yilmaz . 美国分析化学（英文） . 2017,第9期
• 5. ａ-羟基-ａ-环戊基苯乙酸乙酯的不对称合成 [C] . 向纪明 . 中国化学会第三届全国分子手性学术研讨会 . 2010
• 6. 3β-羟基-24-降胆-5-烯-23-酸的合成及抗HIV活性化合物OSW-1的合成研究 [A] . 任小娟 . 2009