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method for preparation of fluoreenderivaten, method for preparation of pharmaceutical preparations with anti - viruswerking, which thus prepared fluoreenderivaten containapplication of this method in pharmaceutical preparation was obtained.
method for preparation of fluoreenderivaten, method for preparation of pharmaceutical preparations with anti - viruswerking, which thus prepared fluoreenderivaten containapplication of this method in pharmaceutical preparation was obtained.
1,274,479. Fluorenone, fluorenol and fluorene derivatives. RICHARDSON-MERRELL Inc. 17 Dec., 1969 [30 Dec., 1968], No. 61592/69. Heading C2C. [Also in Division C4] The invention comprises novel compounds I (including acid addition salts and hydrates thereof) where Z is O, (H, H) or (H, OH), Y is O or S, and X is -A-NRRSP1/SP (A is C 2 to C 8 alkylene and separates the N and Y by at least 2 C, R and RSP1/SP are H, alkyl, C 3 to C 6 cycloalkyl, C 3 to C 6 alkenyl having the unsaturation in other than the 1-position of the alkenyl group, or together with the adjacent N comprise a saturated monocyclic heterocycle) or 1a where n is 0 to 2, m is 1 or 2 and RSP2/SP is H, alkyl or C 3 to C 6 alkenyl (same limitation as with the preceding alkenyl). The compounds are made by condensing II with (a) X-halogen, (b) halogen-A-halogen to afford compounds VI which are subsequently reacted with RRSP1/SPNH, or (c) R.RSP1/SP.NCO.ASP1/SP.- halogen or CNASP1/SP-halogen and reducing the intermediate (e.g. 2,7 - bis - (cyanomethoxy)- fluorene), so obtained with LiAlH, (A is ASP1/SPCH 2 ); the products I can be converted into other products I utilizing alkylation, reduction and/or oxidation. Pharmaceutical preparations showing, in particular, prophylactic and antiviral effects contain I as active ingredient; administration may be orally, parenterally and topically.
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