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new derivatives of methyl - 13, 14 - 20 bisdeshydro - erp system particularly useful as inhibitors of the platelet agglomeration and method of preparation
new derivatives of methyl - 13, 14 - 20 bisdeshydro - erp system particularly useful as inhibitors of the platelet agglomeration and method of preparation
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机译：甲基-13，14-20双脱氢-erp系统的新衍生物，特别可用作血小板聚集抑制剂及其制备方法。
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摘要
20-Methyl-13, 14-didehydro- PGl2 derivatives of formula: IMAGE where R is hydrogen or methyl and M is hydrogen or a pharmaceutically acceptable cation have a greater effect than PGl2 or 20-methyl-PGl2 in disaggregating platelets in the bloodstream and in vasodilating action. They can be prepared by dehydrohalogenation of dihalo compounds of formula (II IMAGE where R and M have the meanings given above and X1 and X2 are independently bromine, chlorine or iodine. A sodium or potassium alkoxide is the preferred dehydrohalogenating agent.
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