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NEW 9-FLOOR PRE-PRICE DERIVED AND SEEN TO PROMOTE DESAMMA

机译:推导了新的9层价格,并有望促进DESAMMA

摘要

The active compounds correspond to the general formula I IMAGE in which R1 denotes an alkanoyl group or cycloalkanoyl group having 1 to 8 carbon atoms or a benzoyl group and X represents a fluorine atome, a chlorine atom or an alkanoyloxy group having 3 to 8 carbon atoms. The novel 9-fluoroprednisolone derivatives can be obtained by opening corresponding 9,11 beta -epoxy compounds with hydrogen fluoride or halogenating or esterifying corresponding 9-fluoro derivatives in the 21-position or cleaving a corresponding 17 alpha -cycloalkanecarbonyloxy compound with a trimethylsilyl halide or triphenylmethyl halide. Medicaments which contain at least one of the abovementioned compounds as an active component can be used for the treatment of inflammations.
机译:活性化合物对应于通式I ,其中R1表示具有1至8个碳原子的烷酰基或环烷酰基或苯甲酰基,并且X表示氟原子,氯原子或具有3至8个烷氧基的烷氧基。碳原子。新的9-氟泼尼松龙衍生物可以通过用氟化氢打开相应的9,11β-环氧化合物或在21位上卤化或酯化相应的9-氟衍生物或用三甲基甲硅烷基卤化物裂解相应的17α-环烷羰基氧基化合物来获得。三苯基甲基卤。包含至少一种上述化合物作为活性成分的药物可以用于治疗炎症。

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