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method for the separation of a urokinase and a group, which contains another urokinase and farmer ceutisch preparation and method for preparing it.
method for the separation of a urokinase and a group, which contains another urokinase and farmer ceutisch preparation and method for preparing it.
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机译：分离尿激酶和一种基团的方法，该组含有另一种尿激酶和农民的制备方法及其制备方法。
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摘要
Sepn. of a urokinase with a mol. wt. of ca. 54,000 (urokinase II) and a fraction contg. a urokinase with a mol. wt. of ca. 33,000 (urokinase I) from mixts. contg. them is effected by chromatographing a buffer soln. of the mixt. on an ion exchange resin, eluting with a concn. gradient of buffer salt. Also claimed is a pharmaceutical compsn. contg. urokinase II and 1 wt. % urokinase I. Since urokinase II has higher activity than I w.r.t. natural glutamyl-plasminogen and is equally active w.r.t. lysyl-plasminogen, it can be used as a thrombolytic agent at lower doses than conventional mixts. of I and II.
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