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Phenylalkylamines and phenylalkylureas in combinations to suppress gastric bleeding in aspirin therapy
Phenylalkylamines and phenylalkylureas in combinations to suppress gastric bleeding in aspirin therapy
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机译：苯烷基胺和苯烷基脲联合使用可抑制阿司匹林治疗中的胃出血
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摘要
Novel pharmaceutical methods, combinations and compositions for reducing gastric bleeding during aspirin therapy for inflammation are disclosed. Compounds used in combination with aspirin are phenylalkylamines and phenylalkylureas having the formula: ##STR1## wherein Z is selected from the group consisting of --NHR.sup.2 or ##STR2## and R is selected from the group consisting of hydrogen, halogen, lower-alkoxy and trifluoromethyl and R. sup.1, R.sup.2, R.sup.3 and R.sup. 4 are selected from the group consisting of hydrogen and lower-alkyl, where R.sup.3 and R.sup.4 taken together with the adjacent nitrogen atom may form a heterocyclic ring selected from the group of piperidino, pyrrolidino, piperazino, and morpholino.
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