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Synthetic polyoxin type nucleosides

机译:合成的多氧合型核苷

摘要

A novel class of intermediates from which a variety of uronic acid nucleosides can be produced, said class being represented by the following formula: ##SPC1##PPWherePPR.sub. 1 and R.sub.2 are lower alkyl radicals having one to six carbon atoms, or phenyl radicals; PPR.sub.3 is a lower alkyl radical having one to four carbon atoms; and the wavy line at the 5' position indicates both the 5'-D-allo and 5'-L-talo epimers.PPA process for producing these intermediates is described. A process for converting these intermediates to uronic acid nucleosides having the following formula: ##SPC2##PPWherePPB is a pyrimidine or purine base, is also described.PPNovel uronic acid nucleosides, having structures falling within the general formula given above, are identified.
机译:可以从中生产各种糖醛酸核苷的新型中间体,所述中间体由下式表示:其中,P> R> R。 1和R 2是具有1-6个碳原子的低级烷基或苯基。 P P R 3是具有1-4个碳原子的低级烷基。并且在5'位置的波浪线表示5'-D-allo和5'-L-talo差向异构体。[P]

描述了生产这些中间体的方法。还描述了将这些中间体转化为具有下式的糖醛酸核苷的方法:其中,P是嘧啶或嘌呤碱。鉴定了具有落入以上给出的通式内的结构的新的糖醛酸核苷。

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