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PROCESS FOR THE MANUFACTURE OF HYOSCINE (SCOPOLAMINE) OR ITS SALT IN A PURE FORM FROM PLANT MATERIAL OF SPECIES SUCH AS DATURA STRAMONIUM OR ATROPA BELLADONNA WHICH CONTAINS THE TOTAL ALKALOIDS CONSISTING OF HYOSCYAMINE AND HYOSCINE
PROCESS FOR THE MANUFACTURE OF HYOSCINE (SCOPOLAMINE) OR ITS SALT IN A PURE FORM FROM PLANT MATERIAL OF SPECIES SUCH AS DATURA STRAMONIUM OR ATROPA BELLADONNA WHICH CONTAINS THE TOTAL ALKALOIDS CONSISTING OF HYOSCYAMINE AND HYOSCINE
WE CLAIM :~ 1. A, process of preparing hyoscine (scopolamine) iu a pure form from plant material of species such a Datura stramonium which contains the total alkaloids consisting of hyoscyamine and hyoscine which consists of the following steps, namely a) isolating the total alkaloids from Datura stramonium by macerating the 16 mesh powder of the leaves with 10% ammonia and extracting with benzene, ethy-lene dichioride or toluene, and obtaining the total alkaloids by shaking the benzene extract with dilute sulphuric acid, basifying with alkalies and extracting the alkaloids with chloroform, and concentrating the chloroform extract to obtain the total alkaloids in fairly pure form, (b) fractionating hyoscine and hyoscyamine by dissol ving the total alkaloids in normal sulphuric acid, neutralising the acidic solution with sodium bicarbonate to a pH 5.6 and extracting with chloroform when hyoscine (Scopoiaaune; is fractionally extracted leaving behind hyoscyamine, and (c) purifying scopolamine by preparing ^scopolamine hydrobromide by reacting wiili nydrobromic acid in acetone solution; tne mixture on allowing to stand overnight in ice chest gives nyoscine hydrobromide.
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机译： Natural (天然) and units (高单位) nutrients (营养素) 13 one component (成分) Total (综合) Vitality (活力) Samtoh, high natural nutritious foods (食品) of the name is excellent (优秀) a domestic natural raw materials (国产自然原料) using 12 species (利用) and processing (加工处理) and a method of manufacturing (制造方法)
