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OKISO 1*22 BENZOCHIAJIN 1*11 JIOKISHIDONOKARUBOKISAMIDO NO SEIHO
OKISO 1*22 BENZOCHIAJIN 1*11 JIOKISHIDONOKARUBOKISAMIDO NO SEIHO
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机译:1月22日本津市阿金1月11日1月11日萨米多(Karuboki Samido)Seiho
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摘要
Disclosed herein is an improved process for the production of carboxamides of 3,4-dihydro-oxo-1,2-benzothiazine-1,1-dioxides. Said process comprises contacting either a 3-oxo- or 4-oxo-1,2-benzothiazine-1,1-dioxide with a known or readily prepared phenylisocyanate to produce the corresponding 4- or 3-carboxanilide followed by a transamidation with an amine whose own isocyanate is frequently unstable to produce carboxamide with previously disclosed pharmaceutical value as a non-steroidal anti-inflammatory agent.
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