首页> 外国专利> METHOD OF PREPARATION Having applied this method, the authors obtained irregular and halogen-steroids of the Erengan series with valuable properties. The proposed method for obtaining the halo-15 steroids of the pregan series of the formula I = 2t L • Where Z is two aliphatic, aromatic or araliphatic hydrocarbon residues, or group ~ .C == Z— cycloalkylideic / / group and X is a fluorine or chlorine atom, consists in the fact that in the compound of formula II there are 'dH.FCHoF20, where RI and Rj are each free or etherified: 1 - or to the ether of oxygram or Ri together with R2 - group 2530 where RI and R2 have the indicated values epoxide ring cleaved action halo- geivodoroda HX, wherein X has the abovementioned meaning, or using an agent-releasing this galogeivodorod and the resulting halogen- gndrin simultaneously or sequentially dehydrated by treatment with hydrogen knslotoy halogen.

METHOD OF PREPARATION Having applied this method, the authors obtained irregular and halogen-steroids of the Erengan series with valuable properties. The proposed method for obtaining the halo-15 steroids of the pregan series of the formula I = 2t L • Where Z is two aliphatic, aromatic or araliphatic hydrocarbon residues, or group ~ .C == Z— cycloalkylideic / / group and X is a fluorine or chlorine atom, consists in the fact that in the compound of formula II there are 'dH.FCHoF20, where RI and Rj are each free or etherified: 1 - or to the ether of oxygram or Ri together with R2 - group 2530 where RI and R2 have the indicated values epoxide ring cleaved action halo- geivodoroda HX, wherein X has the abovementioned meaning, or using an agent-releasing this galogeivodorod and the resulting halogen- gndrin simultaneously or sequentially dehydrated by treatment with hydrogen knslotoy halogen.

机译:制备方法应用该方法,作者获得了具有有价值特性的Erengan系列不规则和卤素类固醇。拟议的获得式I = 2t L的pregan系列卤素15甾族化合物的方法•其中Z为两个脂族,芳族或芳脂族烃残基,或基团〜.C == Z-环烷基/ /和X是氟或氯原子,其原因在于在式II的化合物中存在'dH.FCHoF20,其中RI和Rj各自为游离或醚化的:1-或为氧基或R2的醚与R2-基团2530,其中R 1和R 2具有指示的值,环氧化物裂解的卤代基奥多洛达HX,其中X具有上述含义,或使用释放该高代基奥多洛德的试剂和所得的卤素-nd德林同时或通过用氢钾钾处理而顺次脱水。

摘要

Halo-pregnanes, anti-inflammatories Novel compds. of formula (I) and their 1-dehydro derivs. (where R1, R2 = free, esterified or etherified OH, or together are: Z = 2 aliphatic, aromatic or araliphatic hydrocarbon radicals, or C = Z is cycloalkylidene; and X is H, F or Cl), are prepd. by (a) introduction of DELTA6-6-fluoro- or -chloro grp. into the corresp. 6-unsubstd.-6,7-dihydro derivs of (I), or (b) introduction of a 16-alpha-hydroxy group in the 16-unsubstd. derivs. of (I) or their 1-dehydro derivs., and opt. introducing another double bond in the 1,2-posn., freeing the esterified OH grps. splitting the ketals and/or transforming the 16,17-diols into their 16- and/or 17-monoesters or diesters, or 16,17-monoether or 16,17-ketals. (I) have anti-inflammatory, gestagenic and ovulation-retarding activity.
机译:卤代孕烷,抗炎小说。式(I)的化合物及其1-脱氢衍生物。 (其中R 1,R 2 =游离的,酯化的或醚化的OH,或一起是:Z = 2个脂族,芳族或芳脂族烃基,或C = Z是环亚烷基;且X是H,F或Cl)。通过(a)引入DELTA6-6-氟-或-氯grp。进入Corresp。 (I)的(6-)-6,7-二氢衍生物,或(b)在16-未取代基中引入16-α-羟基。派生。 (I)或它们的1-dehydro衍生物,并选择在1,2-位引入另一个双键,从而释放出酯化的OH基团。分离缩酮和/或将16,17-二醇转变为它们的16-和/或17-单酯或二酯,或16,17-单醚或16,17-缩酮。 (I)具有抗炎,促妊娠和促排卵作用。

著录项

获取专利

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号