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method the blood cholesterol lowering and gallstones muodo stu preventive phenoxy - isovoihappoesterien fluorijohdannaisten val assembly.
method the blood cholesterol lowering and gallstones muodo stu preventive phenoxy - isovoihappoesterien fluorijohdannaisten val assembly.
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机译：方法降血脂和预防胆结石预防苯氧基-异硫杂多酯荧光素的组装。
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1,218,817. Fluoroderivatives of phenoxyisobutyric acid esters. SOC. D'ETUDES SCIENTIFIQUES ET INDUSTRIELLES DE L'lLEDE-FRANOE. 22 Aug., 1968 [26 Sept., 1967; 22 Dec., 1967], No. 40281/68. Heading C2C. Novel compounds of the formula in which R is a straight or branched chain C 1-5 alkyl radical, and X is a CF 3 -, CF 3 S-, CF 3 S(O)-, or CF 3 SO 2 - radical, are obtained by treating an X-substituted phenol with chloroform and acetone in the presence of potash to form the corresponding phenoxy isobutyric acid which is then converted into an ester by a C 1-5 alkanol. The following intermediates are also described p-Nitrotribromomethylbenzene is obtained by reacting p-nitrotoluene with bromine; p-trifluoromethylnitrobenzene is obtained by treating the previous product with SbF 3 ; p-trifluoromethylaniline is obtained by reducing the previous product with SnCl 2 ; p-trifluoromethylphenol is obtained by diazotizing and hydrolysing the previous product. p-Nitrophenylmethyl sulphide is obtained by reacting p-chloronitrobenzene with Na 2 S followed by refluxing with dimethylsulphate, then the product is chlorinated to form p-nilrophenyl trichloromethyl sulphide, which is reacted with SbF 3 to form p-nitrophenyl trifluoromethyl sulphide and the latter is reduced with SnCl 2 in HCl to yield p-aminophenyltrifluoromethyl sulphide; the latter is diazotized and hydrolysed to p-hydrophenyltrifluoromethylsulphide; p-trifluoromethylsulphinylphenoxy isobutyric acid is obtained by oxidizing p-trifluoromethylthiophenoxy isobutyric acid with sodium metaperiodate; p-trifluoromethylsulphonylphenoxy isobutyric acid is obtained by refluxing ptrifluoromethylthiophenoxy isobutyric acid dissolved in a mixture of acetic acid and oxygenated water for 3 hours. Pharmaceutical compositions useful as hypocholesterolemiants and biliary lithiasis preventatives comprise compounds of the above formula in the form of capsules or jelly pills.
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