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Steroids of the OEF series and processes for their manufacture
Steroids of the OEF series and processes for their manufacture
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机译：OEF系列的类固醇及其制造方法
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摘要
The invention comprises new steroids of the oestrane and lumi-oestrane series having the partial general formula: FORM:0974147/C1/1 (where only the A, B and C rings are shown) and in which R and R1 may be the same or different alkyl groups containing 1-6 carbon atoms or together represent a heterocyclic or carbocyclic residue containing 4-5 carbon atoms, n is an integer from 2-5 and the D ring may be unsubstituted or bear any of the usual substituents, non-toxic salts thereof, pharmaceutical compositions thereof, and a process for the preparation thereof by reacting an oestrane or lumioestrane of the formula: FORM:0974147/C1/2 wherein R, R1 and n are as defined above, with a tertiary amine of the formula: FORM:0974147/C1/3 wherein X is a halogen atom other than fluorine, in a lower alcohol and in the presence of the alkali metal alcoholate corresponding thereto. Said pharmaceutical compositions, having antilipaemic activity, are employed orally as tablets, lozenges, transcutaneously as sterile solutions or suspensions or rectally as suppositories.
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