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in zweistellung substituted 3 - aryl - 4 - oxo - 3.4 - dihydrochinazoline, their production and use
in zweistellung substituted 3 - aryl - 4 - oxo - 3.4 - dihydrochinazoline, their production and use
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机译：韦斯特隆中的3-取代基-芳基-4-氧代-3.4-二氢杂唑啉的合成，生产和使用
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摘要
Novel compounds of the general formula FORM:1038729/C2/1 and their acid addition salts, in which R is hydrogen, an alkyl or alkoxy radical containing up to 5 carbon atoms, or a halogen atom (especially chlorine), R1 is hydrogen or an alkyl radical containing up to 4 carbon atoms, R2 is an alkyl radical containing up to 4 carbon atoms, a hydroxyalkyl radical containing up to 4 carbon atoms, a cycloalkyl radical (containing 5 or 6 carbon atoms), or an amino radical, or R1 and R2 together with the adjacent nitrogen represent a saturated mononuclear heterocyclic group, especially 1-pyrrolidyl, 1-piperidyl, morpholino, or 4-alkyl- or 4-hydroxyalkyl-1-piperazinyl (the alkyl and hydroxyalkyl groups containing up to 4 carbon atoms) are prepared by condensing an amine of formula HNR1.R2 with a 2-chloro-quinazoline of the formula FORM:1038729/C2/2 The 2-chloro-quinazolines are prepared by reacting a compound of the general formula FORM:1038729/C2/3 with sulphur monochloride or sulphuryl chloride. Pharmaceutical compositions, preferably in conventional form for oral or parenteral administration, comprise a compound of the first general formula above, or an acid addition salt thereof, and a pharmaceutical carrier. They have sedative and hypnotic activity.
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