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Malignant glioma CAR-T therapeutic vector based on OCTS technology, and construction method and application thereof
Malignant glioma CAR-T therapeutic vector based on OCTS technology, and construction method and application thereof
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机译：基于OCT技术的恶性胶质瘤Car-T治疗载体及其施工方法及应用
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摘要
An OCTS-based CAR-T vector for treating malignant glioma includes lentiviral skeleton plasmid, human EF1α promoter (SEQ ID NO.14), OCTS chimeric receptor structural domain, and PDL1 single-chain antibody; the OCTS chimeric receptor structural domain consists of CD8 leader chimeric receptor signal peptide (SEQ ID NO.15), PDL1 single-chain antibody light chain VL (SEQ ID NO.16), PDL1 single-chain antibody heavy chain VH (SEQ ID NO.17), EGFRvIII single-chain antibody light chain VL (SEQ ID NO.18), EGFRvIII single-chain antibody heavy chain VH (SEQ ID NO.19), antibody Inner-Linker (SEQ ID NO.20), single-chain antibody Inter-Linker (SEQ ID NO.21), CD8 Hinge chimeric receptor linker (SEQ ID NO.22), CD8 Transmembrane chimeric receptor transmembrane domain (SEQ ID NO.23), TCR chimeric receptor T cell activation domain (SEQ ID NO.26) and chimeric receptor co-stimulator domain.
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机译：用于治疗恶性胶质瘤的八磺基型Car-T载体包括慢病毒骨架质粒，人EF1α启动子（SEQ ID NO.14），OCT嵌合受体结构结构域，和PDL1单链抗体; OCT嵌合受体结构域由CD8引导嵌合受体信号肽（SEQ ID NO.15），PDL1单链抗体轻链VL（SEQ ID NO.16），PDL1单链抗体重链VH（SEQ ID NO .17），EGFRVIII单链抗体轻链VL（SEQ ID NO.18），EGFRVIII单链抗体重链VH（SEQ ID NO.19），抗体内部接头（SEQ ID NO.20），单一 - 链抗体接头（SEQ ID NO.21），CD8铰链嵌合受体接头（SEQ ID NO.22），CD8跨膜嵌合受体跨膜结构域（SEQ ID NO.23），TCR嵌合受体T细胞活化域（SEQ ID NO.26）和嵌合受体共刺激域。
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