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METHOD FOR INDUCING ORAL TOLERANCE BY ADMINISTERING PEPTIDES DERIVED FROM BETA-LACTOGLOBULIN IN A COMBINATION WITH A PROBIOTIC
METHOD FOR INDUCING ORAL TOLERANCE BY ADMINISTERING PEPTIDES DERIVED FROM BETA-LACTOGLOBULIN IN A COMBINATION WITH A PROBIOTIC
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机译：通过以益生菌组合施用β-乳酰蛋白酶的肽诱导口服耐受的方法
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FIELD: immunology.;SUBSTANCE: group of inventions relates to compositions for use in inducing oral tolerance and/or for use in treating and/or preventing allergy to cow milk protein. Inventions are based on the use of Bifidobacterium breve and 2–10 different peptides containing an amino acid sequence, consisting of 12–30 consecutive amino acids from the region encompassing amino acids 13 to 48 of the beta-lactoglobulin protein represented by SEQ ID NO: 1, to produce a composition for treating, preventing or reducing the risk of allergy to cow milk protein (CMA) in a patient.;EFFECT: invention enables to significantly reduce allergic reaction to cow milk when using a mixture of peptides with Bifidobacterium breve in comparison with their use separately; combined action of peptide mixture and Bifidobacterium breve reduces synthesis of cytokines induced by an allergen, and prevents development of stronger symptoms of anaphylactic shock.;16 cl, 5 dwg, 3 tbl, 4 ex
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机译：现场：免疫学。物质：本发明组涉及用于诱导口服耐受性和/或用于治疗和/或用于治疗和/或预防牛奶蛋白的过敏的组合物。发明基于使用含有氨基酸序列的双歧杆菌和2-10种不同肽的使用，该氨基酸序列由包括由SEQ ID NO表示的β-乳酰蛋白蛋白的氨基酸13至48的区域组成的12-30个连续的氨基酸： 1，制备用于治疗，预防或降低患者牛奶蛋白（CMA）的过敏的组合物的组合物。;效果：在使用具有双歧杆菌的肽的混合物时，使发明能够显着降低对牛奶的过敏反应与分别使用的比较;肽混合物和双歧杆菌的组合作用缩短了过敏原诱导的细胞因子的合成，并防止发育过敏性休克的更强症状。; 16 cl，5 dwg，3 tbl，4例
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