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SYSTEMS AND METHODS FOR HIGH-THROUGHPUT SCREENING AND ANALYSIS OF DRUG DELIVERY SYSTEMS IN VITRO
SYSTEMS AND METHODS FOR HIGH-THROUGHPUT SCREENING AND ANALYSIS OF DRUG DELIVERY SYSTEMS IN VITRO
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机译：高通量筛选和体外药物递送系统分析的系统和方法
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摘要
The present disclosure provides a method for screening drug delivery vehicles for use in delivering cargo via oral delivery. The method includes introducing a drug delivery vehicle comprising an imaging agent into a lumen of an artificial intestine system composed of a scaffold matrix material. The scaffold matrix material includes an interconnected network of pores, intestinal epithelial cells positioned on an inner surface of the lumen, and human-based cells positioned within the pores and surrounding the intestinal epithelial cells. The method includes maintaining the artificial intestine system in physiologically relevant conditions for a predetermined length of time, and detecting a color change induced by the imaging agent within at least a portion of the human-based cells.
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