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NON-OPIOID COMPOSITIONS AND THERAPIES FOR PAIN MANAGEMENT
NON-OPIOID COMPOSITIONS AND THERAPIES FOR PAIN MANAGEMENT
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机译：非阿片类药物组合物和疼痛管理疗法
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摘要
A composition for treating pain includes an antibody or antibody fragment that specifically binds to a receptor involved in pain. In some embodiments, the receptor is a P2X family receptor such as, for example, P2X4. In some embodiments, the antibody includes a detectable marker. In some of these embodiments, the detectable marker includes a fluorescent tag. The composition may be used to treat acute or chronic pain in a subject. Generally, the methods includes administering to the subject a composition that includes an antibody or antibody fragment that specifically binds to a receptor involved in pain. The non-opioid pain relief composition can reverse pain related mechanical, cold, anxiety-like, and depression-like behaviors in neuropathic pain and chemotoxic nerve injury models.
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