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Treatment of meningiomas using phenylbenzothiazole, stilbene, biphenylalkyne, or pyridine derivatives

机译：使用苯基苯并噻唑，斯蒂尔贝烯，Biphenylalkyne或吡啶衍生物治疗脑膜瘤

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摘要

A method and composition for treating a meningioma in a subject are disclosed. The method includes the step of administering to the subject a therapeutically effective amount of a composition including a cytotoxic agent associated with a phenylbenzothiazole derivative or a stilbene derivative or a biphenylalkyne derivative that accumulates within meningiomas. In one version of the method, the phenylbenzothiazole derivative is a compound of formula (V):; embedded image

机译：公开了用于治疗受试者中脑膜瘤的方法和组合物。该方法包括向受试者施用治疗有效量的组合物，该组合物包括与苯基苯甲酸噻唑衍生物或斯蒂烯衍生物或积聚在脑膜瘤内的苯乙烯衍生物或联苯基烷基衍生物相关的细胞毒性剂。在该方法的一种版本中，苯基苯并噻唑衍生物是式（V）的化合物： <化学ID =“Chem-US-00001”> “嵌入式图像”文件=“US10940218-20210309-C00001.gif”他=“15.83mm”ImgContent

“嵌入式图像”文件=“US10940218-20210309-C00001.gif”他=“15.83mm”ImgContent

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公开/公告号US10940218B2

专利类型
公开/公告日2021-03-09

原文格式PDF
申请/专利权人 MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH;
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申请/专利号US201715472763
发明设计人 GEOFFREY B. JOHNSON;VAL J. LOWE;MARK A. NATHAN;JOSEPH E. PARISI;
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申请日2017-03-29
分类号A61K51;A61M36/14;A61K51/04;A61K31/428;A61K49;A61K49/10;A61K45/06;
国家 US
入库时间 2022-08-24 17:34:49

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