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SYSTEM FOR INDUCING SONOPORATION OF A DRUG INTO CANCER CELLS AND METHOD THEREOF

机译：诱导药物Sounoporation进入癌细胞的系统及其方法

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摘要

System for inducing sonoporation of a drug into cancer cells in a tumor and method thereof, the system comprising a generator configured to provide electrical energy at an ultrasound frequency; an ultrasound probe electrically connected to the generator and configured to convert the electrical energy into low intensity pulsed ultrasonic waves defined by operation parameters, said operation parameters comprising the frequency, the duty cycle, the operation time of the ultrasonic waves; an input device enabling an operator to enter configuration data comprising: type of tumor, type of drug, localization of secondary tumor, anthropometric measurements and grade of tumor, and a processor configured to determine the values of the operation parameters on the basis of the entered configuration data and control the generator and the ultrasound probe to operate according to said determined values, wherein the value of the frequency is determined on the basis of the type of tumor, the localization of the tumor, the grade of tumor and the anthropometric measurements, the value of the duty cycle is determined on the basis of the drug, the type of tumor and the grade of the tumor, and the value of said operation time being determined on the basis of at least the type of tumor and the type of drug.

机译：用于在肿瘤和方法中诱导药物中药物的声孔的系统，该系统包括发电机，该发电机被配置为在超声频率下提供电能;超声波探头电连接到发电机，并且被配置为将电能转换为由操作参数定义的低强度脉冲超声波，所述操作参数包括频率，占空比，超声波的操作时间;一种输入设备，使操作员进入配置数据，包括：肿瘤类型，药物类型，次级肿瘤的定位，肿瘤的人体测量和等级，配置为基于所输入的操作参数的值来确定操作参数的值配置数据和控制发电机和超声探头以根据所述确定的值操作，其中频率的值是基于肿瘤的类型确定的，肿瘤的定位，肿瘤等级和人体测量测量，占空比的值是基于药物，肿瘤的类型和肿瘤的等级确定的值，以及所述操作时间的值基于至少一种肿瘤类型和药物类型确定。

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公开/公告号US2021069332A1

专利类型
公开/公告日2021-03-11

原文格式PDF
申请/专利权人 PIERANGELA GIUSTETTO;FREEDOM WAVES S.R.L.;
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申请/专利号US201816955457
发明设计人 PIERANGELA GIUSTETTO;DANIELE FALETTO;
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申请日2018-12-21
分类号A61K41;A61K31/337;A61K31/704;A61K31/4745;A61K31/513;A61P35;A61N7;G16H20/17;G16H50/70;G16H40/67;G16H40/40;G16H70/40;G16H70/60;G16H50/50;B06B1/02;
国家 US
入库时间 2022-08-24 17:39:07

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