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Composition for prevention, treatment or improvement of prostatic disease including goat, rocone and red pine extract as active ingredient

机译：预防，治疗或改善前列腺疾病的组合，包括山羊，罗酮和红松提取物作为活性成分

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摘要

The present invention relates toGoblinLocoContains pine wood extract as an active ingredientPrevention of prostate diseaseTreatmentOrEnglish translationLocoComposite extract of red pine andIt has the effect of suppressing the activity of the 5-alpha reductase associated with prostatic hypertrophy.By using natural ingredients from plantsIt was seen in the pastThere is an advantage in that there is little or no side effect such as the lowering of the sexual function of the man by the synthesis compound.The present invention also confirms that the mixed extract mixed at an appropriate ratio is significantly superior to the inhibitory activity of the 5-alpha reductase than in each of the goat, rokko, and Akamatsu pine extracts, and substitutes the import compound which is dependent upon the import for prevention or treatment of benign prostatic hypertrophy .Diagram

机译：本发明涉及GineBolocontains松木提取物作为前列腺脱离病疗法的活性成分PreventeRenglish英语翻译中翻译的红松，具有抑制与前列腺肥大相关的5-α还原酶活性的效果。在麦克斯特中看到使用自然成分的效果。是一个优点在于几乎没有副作用，例如通过合成化合物降低人类的性函数。本发明还证实以合适的比例混合的混合萃取物显着优于抑制活性5-α还原酶比山羊，rokko和akamatsu松草提取物中的每一个，并替代导致依赖于预防或治疗良性前列腺肥大.diagram的进口化合物

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公开/公告号JP2021508735A

专利类型
公开/公告日2021-03-11

原文格式PDF
申请/专利权人ゲノムアンドメディスンカンパニーリミテッド;
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申请/专利号JP20200554996
发明设计人イミンウォン;ユンギュヒョン;イユンオク;ユンソンヘ;ユンジェスン;
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申请日2018-11-19
分类号A61K36/899;A61K36/254;A61K36/15;A61P13/08;A61P43;A23L33/105;A61P35;
国家 JP
入库时间 2022-08-24 17:39:53

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3. Scarless Wound Healing Gel with Binahong (Anredera cordifolia (Ten) Steenis) Leaves Extract and Celecoxib as the Active Ingredients [C] . Enade Perdana Istyastono, Sri Hartati Yuliani International Conference on Science and Technology . 2016

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V Garcia-Martinez, C Lopez Sanchez, W Hamed, 2016

7. RIVP-GLIPR-LIKE Compositions and Methods for the Detection, Treatment and Prevention of Prostate Cancer. [R] . Thompson, T. C., Ren, C. 2005

1. Highly Active Antiretroviral Treatment (HAART) for the Prevention of HIV Mother to Child Transmission (PMTCT) at Roosevelt Hospital's Infectious Diseases Clinic in Guatemala: The Role of (LPV/r) Standard Dose [J] . Carlos Mejia Villatoro ,Maria Eugenia Luarte ,Guillermo Villatoro Natareno . 艾滋病（英文） . 2012,第3期

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5. 两种中药中抗前列腺疾病活性成分的研究 [A] . 韩慧英 . 2007