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Combined antibacterial composition and short-term antibacterial regimen

机译:组合抗菌组合物和短期抗菌方案

摘要

PROBLEM TO BE SOLVED: To provide a therapeutic combination with antibacterial agents linezolid, bedaquiline and pretomanid, and optionally pyrazinamide in a short-term oral administration regimen for the treatment of tuberculosis. A method for the treatment of tuberculosis is also provided, which is pharmaceuticallyd to patients in need, linezolid, bedaquiline and pretomanid, and optionally pyrazinamide, or each of these. Includes each therapeutically effective amount of acceptable salt, as well as the step of administering a pharmaceutically acceptable carrier. In one embodiment of the invention, linezolid is removed from the treatment regimen after 1-2 months. In another embodiment, linezolid can be re-administered after a 1-2 week washout. [Selection diagram] None
机译:要解决的问题:提供与抗菌剂LINEZOLID,BEDAQUILINE和PRETOMANID的治疗组合,以及任选的吡嗪酰胺在短期口腔施用方案中用于治疗结核病。还提供了一种治疗结核病的方法,其对需要的患者,LINEZOLID,BEDAIRINE和PRETOMANID,以及任选的吡嗪酰胺,或它们中的每一种药物是药学的。包括每种治疗有效量的可接受的盐,以及给药药学上可接受的载体的步骤。在本发明的一个实施方案中,在1-2个月后从治疗方案中除去LINEzolid。在另一个实施方案中,可以在1-2周的冲洗后重新施用LINEzolid。 [选择图]无

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