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Methods and materials for evaluating homologous recombination defects
Methods and materials for evaluating homologous recombination defects
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机译：用于评估同源重组缺陷的方法和材料
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摘要
A method and material involved in evaluating a sample with respect to the presence of homologous recombination deficiency (HRD) or HRD signatures.DNA damaging agentAnthracyclineTopoisomerase I inhibitorAn in vitro method for predicting a patient response to a cancer treatment regimen comprising a PARP or PARP inhibitor;In samples containing cancer cellsIn at least one human chromosome of cancer cells in cancer patientsIndicator LOH regionIndicator TaiOr determining the number of indicator CA regions containing at least two types selected from the indicator LST region;And the indicator LOH region in the sampleIndicator TaiOr the number of indicators LST regions greater than the reference numberIncluding the stage of diagnosing the likelihood of responding to the cancer treatment regimenMethod.No selection
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