首页> 外国专利> Evaluation method of renal function and method of discriminating patients with diabetic patients with decreased renal function

Evaluation method of renal function and method of discriminating patients with diabetic patients with decreased renal function

机译:肾功能下降肾功能患者肾功能评价方法及歧视患者患者

摘要

PROBLEM TO BE SOLVED: To provide a novel method for evaluating the degree of renal function or tubular disorder and a method for discriminating a diabetic patient having decreased renal function or a diabetic patient having renal tubular disorder. According to the present invention, a method for evaluating the degree of renal dysfunction or renal tubule disorder and renal function, including a step of measuring a level of DNA methylation specific to tubular cells of cells present in urine. A method for determining a diabetic patient with a decreased renal tubule disorder or a diabetic patient with renal tubular disorder is provided. Measurements of tubular cell-specific DNA methylation levels can be made for CpG sites present at the SMTNL2 and / or G6PC loci. [Selection diagram] None
机译:要解决的问题:提供一种评价肾功能或管状病症程度的新方法以及用于区分肾功能下降的糖尿病患者或具有肾小管疾病的糖尿病患者的方法。根据本发明,一种用于评估肾功能障碍或肾小管病症和肾功能的程度的方法,包括测量与尿液中存在的细胞的管状细胞的DNA甲基化水平的步骤。提供了一种用肾小管病症减少的糖尿病患者确定具有肾小管病症的糖尿病患者的方法。可以对SMTN12和/或G6PC基因座存在的CPG位点来制备管状细胞特异性DNA甲基化水平的测量。 [选择图]无

著录项

  • 公开/公告号JP2021040625A

    专利类型

  • 公开/公告日2021-03-18

    原文格式PDF

  • 申请/专利权人 国立大学法人 東京大学;

    申请/专利号JP20200150726

  • 发明设计人 丸茂 丈史;藤田 敏郎;

    申请日2020-09-08

  • 分类号C12Q1/6869;C12Q1/6837;G01N33/493;G01N33/50;G01N33/68;G01N33/70;C12N15/12;

  • 国家 JP

  • 入库时间 2022-08-24 17:48:39

相似文献

  • 专利
  • 外文文献
  • 中文文献
获取专利

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号