首页> 外国专利> DEVELOPMENT OF A NOVEL LIVE ATTENUATED AFRICAN SWINE FEVER VACCINE BASED IN THE DELETION OF GENE I177L

DEVELOPMENT OF A NOVEL LIVE ATTENUATED AFRICAN SWINE FEVER VACCINE BASED IN THE DELETION OF GENE I177L

机译:在缺失基因I177L的缺失时,开发一种小型活病毒的非洲猪瘟疫苗

摘要

Provided herein are details on the construction of a recombinant African Swine Fever Virus (ASFV) live attenuated vaccine for prevention of ASF caused by various strains of ASFV, such as the highly virulent Georgia 2007 isolate (“ASFV-G”). An exemplary vaccine comprises the ASFV-GΔI1771 modified virus, a recombinant ASFV-G modified by deleting a portion of the I177L ORF rendering the I177L gene nonfunctional.
机译:本文提供了关于重组非洲猪瘟病毒(ASFV)的结构的详细信息,用于预防由各种ASFV菌株引起的ASF,例如高毒性的Georgia 2007分离物(“ASFV-G”)的衰减疫苗。示例性疫苗包括ASFV-GΔI1771改性病毒,通过删除I177L ORF的一部分来改性重组ASFV-G,使I177L基因无功能。

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