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Nanoporous gold and silver nanoparticles and substrates for molecular and biomolecular sensing
Nanoporous gold and silver nanoparticles and substrates for molecular and biomolecular sensing
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机译：纳米多孔金和银纳米粒子和用于分子和生物分子感测的底物
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摘要
A methodology for assays and diagnostics utilizes a nanoporous or corrugated metal-containing surface, fiber or particle which enhances or suppresses the optical detectability of a label. The resulting optical, electromagnetic, or imaging signal signals the presence of a pathogen or analyte of interest. Preferred embodiments pertain to label-free, in situ monitoring of individual DNA hybridization in microfluidics using molecular sentinel probes immobilized on nanoporous gold disks. By immobilizing molecular sentinel probes on nanoporous gold disks, single-molecule sensitivity is demonstrated via surface-enhanced Raman scattering which provides robust signals. The described methodology is generally applicable to most amplification independent assays and molecular diagnostics.
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