首页> 外国专利> Tetra-specific, octameric binding agents and antibodies against Clostridium difficile toxin A and toxin B for treatment of C. difficile infection

Tetra-specific, octameric binding agents and antibodies against Clostridium difficile toxin A and toxin B for treatment of C. difficile infection

机译：TETRA特异性的，八大聚酰胺结合剂和抗腹腹腹腹梭菌的抗体用于治疗 C的毒素A和毒素B.艰难岩感染

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摘要

Novel, antibody-based binding agents derived from human and camelid immunoglobulins are described. These binding agents recognize and bind with specificity to Clostridium difficile toxin A and/or toxin B and in some cases exhibit toxin neutralizing activity. These binding agents can be used to treat or prevent primary and recurrent CDI. The binding agents include camelid V_HH peptide monomers, linked groups of V_HH peptide monomers, V_HH peptide monomers joined to antibody Fc domains, and V_HH peptide monomers joined to IgG antibodies. 展开▼

机译：描述了衍生自人和骆驼藻免疫球蛋白的基于抗体基结合剂。这些结合剂识别并与梭菌梭菌毒素A和/或毒素B的特异性结合，并且在某些情况下表现出毒素中和活性。这些结合剂可用于治疗或预防原发性和复发性CDI。结合剂包括骆驼醛v <亚> H肽单体，v _{h + h肽单体的连接基团，V _{h h肽单体连接到抗体fc结构域，v _{h肽单体连接到IgG抗体。}}} 展开▼

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公开/公告号US10961299B2

专利类型

公开/公告日2021-03-30

原文格式PDF

申请/专利权人 HANPING FENG;YONGJUN GUAN;YONGRONG ZHANG;ZHIYONG YANG;LIANFA SHI;
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申请/专利号US201615548901

发明设计人 HANPING FENG;YONGJUN GUAN;YONGRONG ZHANG;ZHIYONG YANG;LIANFA SHI;
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申请日2016-02-05

分类号C07K16/12;A61P31/04;A61K39;

国家 US

入库时间 2022-08-24 17:58:35

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机译：四环特异性，胆固醇结合剂和抗艰难梭菌毒素A和毒素B的抗体，用于治疗艰难梭菌感染

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机译：四环特异性，胆固醇结合剂和抗艰难梭菌毒素A和毒素B的抗体，用于治疗艰难梭菌感染

5. TETRA-SPECIFIC, OCTAMERIC BINDING AGENTS AND ANTIBODIES AGAINST CLOSTRIDIUM DIFFICILE TOXIN A AND TOXIN B FOR TREATMENT OF C. DIFFICILE INFECTION [P] . 欧洲知识产权局专利： EP3253790A2 . 2017-12-13

机译：四环特异性，胆固醇结合剂和抗艰难梭菌毒素A和毒素B的抗体，用于治疗艰难梭菌感染

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