Disclosed are a type of tridentate linkers and use thereof. The tridentate linkers can be used to prepare an antibody drug conjugates as represented by formula I,L-(T-A-D)n Iwherein, L is an antibody, antibody fragment or protein; T is a tridentate linker part; A is a cleavable linker group or a noncleavable linker part; D is a drug part; n is an integer of 0-8. The structure of the tridentate linker part is as represented by formula II,; wherein, W is substituted aryl, heteroaryl, linear alkyl, cycloalkyl, heterocycloalkyl, or any combination thereof.
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机译：公开了一种三齿接头和其用途。三叉戟接头可用于制备由式I表示的抗体药物缀合物，<？在线 - 公式说明=“线式公式”终止=“铅”？> L-（TAD）<亚> N I <？在线 - 公式描述=“线式公式“结束=”尾“？>其中，L是抗体，抗体片段或蛋白质; t是一个三籍链接部分; A是可切割的接头组或不可分解的接头部分; D是一种药物部分; n是0-8的整数。三叉戟接头部分的结构如公式II所示; <化学ID =“Chem-US-00001”> 其中，W是取代的芳基，杂芳基，线性烷基，环烷基，杂环烷基或其任何组合。
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