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OXALAMIDE COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY

机译：氧化醇酰胺化合物和组合物，用于治疗与刺痛活性相关的病症

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摘要

This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination of the compound) that inhibit (e.g., antagonize) Stimulator of Interferon Genes (STING). Said chemical entities are useful, e.g., for treating a condition, disease or disorder in which increased (e.g., excessive) STING activation (e.g., STING signaling) contributes to the pathology and/or symptoms and/or progression of the condition, disease or disorder (e.g., cancer) in a subject (e.g., a human). This disclosure also features compositions containing the same as well as methods of using and making the same.

机译：本公开内容具有化学实体（例如，化合物或药学上可接受的盐，和/或水合物，和/或化合物的钴和/或药物组合），其抑制干扰素基因的（例如，抗拮抗）刺激剂（刺痛）。所述化学实体是有用的，例如，用于治疗疾病，疾病或病症增加（例如，过量）刺痛激活（例如，尖锐信号）有助于病理，疾病或症状的病理和/或症状和/或进展受试者（例如，人）中的疾病（例如癌症）。本公开还具有含有相同的组合物以及使用和制造该组合物。

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公开/公告号WO2021067791A1

专利类型
公开/公告日2021-04-08

原文格式PDF
申请/专利权人 IFM DUE INC.;
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申请/专利号WO2020US54054
发明设计人 SEIDEL HANS MARTIN;ROUSH WILLIAM R.;KATZ JASON;VENKATRAMAN SHANKAR;
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申请日2020-10-02
分类号C07D471/04;A61K31/437;A61K31/444;A61K31/4453;A61K31/47;A61P25;A61P31/04;A61P31/10;A61P31/14;A61P33;A61P35;A61P37/06;
国家 US
入库时间 2022-08-24 18:09:16

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