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Genetically engineered multi-component system for identification and characterization of T cell receptors, T cell antigens and their functional interactions

机译:基因工程的多组分系统,用于鉴定和表征T细胞受体,T细胞抗原及其功能相互作用

摘要

The present invention relates to a TCR-presenting cell (eTPC) in which the first component is genetically engineered (referred to as component A), wherein component A is an analyte antigen presenting complex (aAPX) and / or an analyte antigenic molecule. A multi-component system lacking endogenous surface expression of at least one family of (aAM) and wherein the second component is a gene donor vector for delivery of an ORF encoding an analyte TCR chain (referred to as component C). [Selection diagram] Fig. 1
机译:本发明涉及一种TCR呈递细胞(ETPC),其中第一组分被遗传工程化(称为组分A),其中组分A是呈现复合物(AAPX)和/或分析物抗原分子的分析物抗原。缺乏至少一个(AAM)的内源性表面表达的多组分系统,其中第二组分是用于递送编码分析物TCR链的ORF的基因供体载体(称为组分C)。 [选择图]图1

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