首页> 外国专利> Managing Cardiovascular Conditions Associated with Kidney Disease

Managing Cardiovascular Conditions Associated with Kidney Disease

机译:管理与肾病相关的心血管病症

摘要

This disclosure relates to managing cardiovascular diseases and conditions associated with kidney disease. In certain embodiments, this disclosure relates to methods of treating or preventing a cardiovascular disease or condition comprising administering an effective amount of a urea transporter inhibitor to a subject in need thereof. In certain embodiments, the subject is diagnosed with kidney disease. In certain embodiments, the subject is diagnosed with uremic cardiomyopathy. In certain embodiments, the urea transporter inhibitor is N,N′-dimethylthiourea (DMTU), prodrug, derivative, or salt thereof.
机译:本公开涉及管理与肾病相关的心血管疾病和病症。在某些实施方案中,本公开涉及治疗或预防心血管疾病或病症的方法,包括向有此需要的受试者施用有效量的尿素转运蛋白抑制剂。在某些实施方案中,受试者被诊断为肾病。在某些实施方案中,受试者被诊断出尿毒症心肌病。在某些实施方案中,尿素转运蛋白抑制剂是N,N'-二甲基脲(DMTU),前药,衍生物或盐。

著录项

  • 公开/公告号US2021106547A1

    专利类型

  • 公开/公告日2021-04-15

    原文格式PDF

  • 申请/专利权人 EMORY UNIVERSITY;

    申请/专利号US202017067477

  • 申请日2020-10-09

  • 分类号A61K31/17;A61K31/585;A61K31/341;

  • 国家 US

  • 入库时间 2022-08-24 18:14:43

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