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Genome assembly method, genome assembly program and genome assembly apparatus

机译:基因组组装方法,基因组组装程序和基因组组装装置

摘要

Problem to be solved: to reduce the computational load and assemble DNA fragments.Computer for theIn the base sequence of the standard genome which is the genome of the organismFor each of the n-base motifs, which are base sequences containing N bases, the rate of occurrence of each standard is the percentage of appearanceAll of the n-base motifs in the base sequence of DNA fragments based on DNA extracted from biological samples are based on the rate of appearance of the sample, which is the rate of occurrence of each.The discrepancy of the sample appearance rate to each standard appearance rate for all N base motifs is calculated.An n-base motif whose sample appearance rate is above a predetermined valueA number of N base motifs are extracted from the lowest degree of deviationThe nucleotide sequence of DNA fragments is converted into DNA fragments of genome map type using an extracted n-base motif.It is assumed that the DNA fragment of the genome map type is assembled to generate the assembly contig of the DNA of the sample.Diagram
机译:要解决的问题:减少计算负荷和组装DNA片段。用于素的计算机的标准基因组的碱基序列是有机体的每个n基序列的基因组,这是含有n个碱基的基本序列,每个标准的发生率是n基碱的呈效果的百分比基于生物样品中提取的DNA的DNA片段碱基序列中的基序基于样品的外观速率,这是每个样品的发生率。样品外观率的差异为所有N的每个标准外观率计算基质图案。从最低程度的偏差提取样品外观速率的N基质图案,其样本外观速率高于预定的N基质基序的N基质基序列的核苷酸序列通过提取的n转化为基因组图类型的DNA片段的核苷酸序列-Base MOTIF.IT被假设组装了基因组图类型的DNA片段以产生样本的DNA的组件CONDIG

著录项

  • 公开/公告号JP2021061829A

    专利类型

  • 公开/公告日2021-04-22

    原文格式PDF

  • 申请/专利权人 株式会社日立ハイテク;

    申请/专利号JP20200171324

  • 发明设计人 永井 健夫;荻野 剛;

    申请日2020-10-09

  • 分类号C12Q1/6869;C12Q1/6827;C12M1;

  • 国家 JP

  • 入库时间 2022-08-24 18:21:36

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