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AhR-ROR-γt complex as a biomarker and therapeutic target for autoimmune diseases and IL-17A-related diseases
AhR-ROR-γt complex as a biomarker and therapeutic target for autoimmune diseases and IL-17A-related diseases
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机译：AHR-ROR-γT复合物作为自身免疫疾病和IL-17A相关疾病的生物标志物和治疗靶标
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摘要
A method of identifying an AhR-phospho-RORγt protein complex inhibitor, comprising: (a) providing a cell culture in which cells in the culture express AhR protein and phospho-RORγt protein; (b) incubating the cell culture in the presence of a test agent; (c) analyzing the level of the AhR-phospho-RORγt protein complex in the presence of the test agent; (d) comparing the level of the AhR-phospho-RORγt protein complex in the presence of the test agent with a control; And (e) when the comparison step indicates that there is a decrease in the level of the AhR-phospho-RORγt protein complex in the presence of the test agent compared to the control, the test agent is used as the AhR-phospho-RORγt protein complex. And identifying as an inhibitor of. Methods of identifying GLK-IQGAP1 protein complex inhibitors are also disclosed. The use of the identified inhibitors in the manufacture of a medicament for treating a disease is also disclosed.
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