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Methods for determining drug efficacy for the treatment of diffuse large B-cell lymphoma, multiple myeloma, and myeloid cancers

机译：确定弥漫性大B细胞淋巴瘤，多发性骨髓瘤和骨髓癌治疗药物疗效的方法

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摘要

Provided herein, in some embodiments, are methods of using certain cereblon-associated proteins, such as Aiolos, Ikaros, interferon (IFN), and IFN pathway proteins, casein kinase 1, alpha 1 (CSNK1A1), and ZFP9, as biomarkers for use in predicting and monitoring clinical sensitivity and therapeutic response to certain compounds in patients having various diseases and disorders, such as cancers (e.g., diffuse large B-cell lymphoma (DLBCL), multiple myeloma (MM), myelodysplasia syndromes (MDS) and acute myeloid leukemia (AML)) and IFN-associated disorders. Also provided herein, in certain embodiments, are methods of determining the efficacy of an immunomodulatory compound.

机译：在本文中，在一些实施方案中，是使用某些未生物蛋白，酪蛋白激酶1，α1（CSNK1A1）和ZFP9作为用于使用的生物标志物的方法在预测和监测具有各种疾病和疾病的患者的某些化合物的临床敏感性和治疗反应时，例如癌症（例如，弥漫性大B细胞淋巴瘤（DLBCL），多发性骨髓瘤（MM），髓细胞综合征（MDS）和急性髓样白血病（AML））和IFN相关的疾病。在某些实施方案中，还提供了确定免疫调节化合物的功效的方法。

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公开/公告号US10996215B2

专利类型
公开/公告日2021-05-04

原文格式PDF
申请/专利权人 CELGENE CORPORATION;
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申请/专利号US201815946618
发明设计人 MATTHEW WILLIAM BURNELL TROTTER;PATRICK HAGNER;COURTNEY G. HAVENS;RAJESH CHOPRA;ANITA GANDHI;ANKE KLIPPEL;MARIA YINGLIN WANG;MIKE BREIDER;SUZANA STURLINI COUTO;YAN REN;PAUL HOLLENBACH;KYLE MACBETH;
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申请日2018-04-05
分类号G01N33/50;A61K31/517;G01N33/68;A61K31/454;A61K31/5377;A61K38/21;C12Q1/6883;C12Q1/6886;G01N33/574;
国家 US
入库时间 2022-08-24 18:31:59

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