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GUIDED MICROBIAL REMODELING, A PLATFORM FOR THE RATIONAL IMPROVEMENT OF MICROBIAL SPECIES FOR AGRICULTURE

机译:引导微生物改造,一种用于农业微生物物种的合理改善的平台

摘要

The present disclosure provides guided microbial remodeling (GMR) methods for the rational improvement of plant-associated microbes to perform plant-beneficial functions. The GMR methods described herein allow for non-intergeneric genetic optimization of key regulatory networks within the microbes, which improve plant-beneficial functions over wild-type microbes but don't have the risks associated with transgenic approaches (e.g., unpredictable gene function, public and regulatory concerns, etc.). The present disclosure also provides remodeled microbes and compositions thereof. The utilization of remodeled microbes and compositions thereof will enable farmers to realize more productive and predictable crop yields without the nutrient degradation, leaching, or toxic runoff associated with traditional synthetically derived fertilizers.
机译:本公开提供了用于合理改善植物相关微生物的引导微生物重塑(GMR)方法以进行植物有益功能。本文所述的GMR方法允许微生物内的关键调节网络的非仲裁遗传优化,从而改善野生型微生物的植物有益功能,但没有与转基因方法相关的风险(例如,不可预测的基因函数,公众和监管问题等)。本公开还提供重新渗透微生物及其组合物。利用改造的微生物和其组合物将使农民能够实现更高效和可预测的作物产量,而没有与传统的合成源性肥料相关的营养降解,浸出或有毒径流。

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