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A method and device for analyzing the elastic property distribution of the cell under test, and a method and device for determining the shape parameters of the probe of the atomic force microscope.
A method and device for analyzing the elastic property distribution of the cell under test, and a method and device for determining the shape parameters of the probe of the atomic force microscope.
PROBLEM TO BE SOLVED: To provide a method and an apparatus for analyzing an elastic property distribution of a cell under test having high spatial resolution, which enables rapid measurement of mechanical properties of a cell or tissue. SOLUTION: The probe is pressed by using a shape parameter determined according to the tip shape of the probe and a model formula expressing the relationship between the deformation amount (d) of the cell to be measured and the pressing force (F) of the probe. The step of calculating the relationship between the amount of cell deformation (d) at the position and the pressing force of the probe (F), the measured value corresponding to the measured amount of deformation of the cell and the pressing force of the probe, and the above model. Using the calculated value calculated by the formula, the step of calculating the shape parameter in which the dispersion value (ΔT) of the matching error is the minimum value for the parameter R, and the shape parameter in which the minimum value is the minimum value of the cell under test It has a step of creating at least one of a stress distribution or an elastic value distribution. [Selection diagram] Fig. 4
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