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METHOD AND DEVICE FOR CLASSIFICATION OF URINE SEDIMENT GENOMIC DNA, AND USE OF URINE SEDIMENT GENOMIC DNA

机译：尿泥沉积物基因组DNA分类的方法和装置，以及尿沉积物基因组DNA的使用

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摘要

The present invention falls within the fields of genomics and bioinformatics, and relates to a classification method, device and use of urine sediment genomic DNA. Specifically, the present invention relates to a DNA classification method, comprising: calculating the MHL value of a DNA methylation haplotype region and/or the DNA copy number variation data of a target sample; calculating the similarity between the MHL value of the DNA methylation haplotype region of the target sample DNA and the MHL value of a DNA methylation haplotype region of each classification label, and/or the similarity between the copy number variation data of the target sample DNA and the DNA copy number variation data of each classification label; and determining the classification to which the target sample DNA belongs by using a classifier model and according to the similarity. The present invention provides a new detection method for urogenital system tumors, which method has good specificity and sensitivity.

机译：本发明落入基因组学和生物信息学的领域，涉及尿沉积物基因组DNA的分类方法，装置和使用。具体地，本发明涉及DNA分类方法，包括：计算DNA甲基化单倍型和/或目标样品的DNA拷贝数变异数据的MHL值;计算靶样样品DNA的DNA甲基化单倍型区域的MHL值与每个分类标签的DNA甲基化单倍型区域的MHL值，和/或靶样样品DNA的拷贝数变异数据之间的相似性和每个分类标签的DNA拷贝数变型数据;通过使用分类器模型并根据相似性确定目标样本DNA所属的分类。本发明提供了一种新的泌尿生殖系统肿瘤检测方法，该方法具有良好的特异性和敏感性。

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公开/公告号WO2021088653A1

专利类型
公开/公告日2021-05-14

原文格式PDF
申请/专利权人 BEIJING INSTITUTE OF GENOMICS CHINESE ACADEMY OF SCIENCES (CHINA NATIONAL CENTER FOR BIOINFORMATION);PEKING UNIVERSITY FIRST HOSPITAL;
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申请/专利号WO2020CN122821
发明设计人 CI WEIMIN;XU ZHENGZHENG;ZHOU LIQUN;
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申请日2020-10-22
分类号G16B30;
国家 CN
入库时间 2022-08-24 18:42:32

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