首页> 外国专利> COMPOSITION FOR PREVENTING OR TREATING KELOID OR HYPERTROPHIC SCAR

COMPOSITION FOR PREVENTING OR TREATING KELOID OR HYPERTROPHIC SCAR

机译:用于预防或治疗瘢痕疙瘩或肥厚瘢痕的组合物

摘要

The present invention relates to a pharmaceutical composition for preventing or treating hypertrophic scars. The present inventors have found that the inhibition of expression of TXNDC5, PRRC1, S100A11, Galectin 1, Filamin A, eIF-5A, Annexin A2, and FABP5 can be a new target for improving and treating hypertrophic scars. In the present invention, TXNDC5-, PRRC1-, S100A11-, Galectin 1-, Filamin A-, eIF-5A-, Annexin A2-, and FABP5-specific siRNAs were constructed to determine the probability of treating the hypertrophic scars. As a result, the knockdown of the protein or a gene encoding the protein induces apoptosis in the hypertrophic scars and reduces collagen expression, which can be very useful in treating wounds.
机译:本发明涉及用于预防或治疗肥厚瘢痕的药物组合物。本发明人发现,抑制TXNDC5,PRRC1,S100A11,GA1Cectin 1,菲素A,EIF-5a,annexin A2和FABP5的表达可以是改善和治疗肥厚疤痕的新靶标。在本发明中,构建了TXNDC5-,PRRC1-,S100A11-,半抗凝蛋白1-,菲素A-,EIF-5A-,annexxin A2-和FABP5特异性siRNA以确定治疗肥厚疤痕的可能性。结果,蛋白质的敲低或编码蛋白质的基因在肥大疤痕中诱导细胞凋亡并减少胶原蛋白表达,这对于治疗伤口非常有用。

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