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PHENOTYPIC PROFILING OF HEPATOCELLULAR CARCINOMA CIRCULATING TUMOR CELLS FOR TREATMENT SELECTION

机译：肝细胞癌循环肿瘤细胞的表型分析进行治疗选择

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摘要

Methods and kits for detecting hepatocellular carcinoma recurrence or metastasis, and of measuring markers of hepatocellular carcinoma, including markers of hepatocellular carcinoma recurrence or metastasis, in a blood sample obtained from a subject by (a) isolating circulating tumor cells (CTCs) by contacting a blood sample obtained from the subject with a set of capture antibodies, wherein the capture antibodies specifically bind asialoglycoprotein receptor (ASGPR), Glypican-3, and epithelial cell adhesion molecule (EpCAM); (b) contacting the isolated CTCs with an antibody that specifically binds vimentin; and (c) measuring the number of vimentin-positive CTC.

机译：检测肝细胞癌复发或转移的方法和试剂盒，以及肝细胞癌的测量标记，包括肝细胞癌复发或转移的标记，在由（a）通过接触a分离循环肿瘤细胞（CTC）获得的血液样品中用具有一组捕获抗体从受试者获得的血液样品，其中捕获抗体特异性结合亚血糖糖蛋白受体（ASGPR），甘氨酸-3和上皮细胞粘附分子（EPCAM）; （b）将分离的CTC与特异性结合Vimentin的抗体接触; （c）测量Vimentin阳性CTC的数量。

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公开/公告号EP3676295A4

专利类型
公开/公告日2021-05-26

原文格式PDF
申请/专利权人 THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;
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申请/专利号EP20180851615
发明设计人 AGOPIAN VATCHE;TSENG HSIAN-RONG;HOU SHUANG;
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申请日2018-08-31
分类号C07K16/28;C07K16/30;G01N33/574;
国家 EP
入库时间 2022-08-24 19:00:33

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