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Three dimensional image analysis of cells and tissues for cell and intracellular morphological modeling and classification

机译:细胞和组织细胞和细胞组织的三维图像分析及细胞内形态学建模和分类

摘要

The ability to automate processes such as sampling, image acquisition, data preprocessing, and derivation of biomarkers, modeling, classification, and analysis processes can significantly affect basic studies of clinical decision-making and cell deformation.This disclosure combines 3D cell shape modeling with robust smooth surface reconstruction and shape morphometric measures to produce highly parallel pipeline workflows ranging from beginning to end of morphological analysis in 3D of thousands of nuclei and nucleoli.This method represents the reproducible technique that can efficiently and efficiently evaluate the cell shape in the image data, and can validate, modify and convert it in a biomedical community.This facilitates the reproducibility of the results, joint verification of the method, and widespread knowledge diffusion.
机译:自动化进程的能力,例如生物标志物的采样,图像获取,数据预处理和推导,建模,分类和分析过程可以显着影响临床决策和细胞变形的基本研究。本公开结合了3D细胞形状建模与鲁棒平滑的表面重建和形状形态测量措施,从数千核和核仁的3D中产生高度平行的管道工作流程,从核心和核仁的3D开始到结束。方法代表了可重复和有效地评价图像数据中的细胞形状的可重复性技术,并且可以在生物医学社区验证,修改和转换它。这有助于再现结果,联合验证方法,以及广泛的知识扩散。

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