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首页> 外国专利> METHOD FOR SIMULATING ATHEROSCLEROSIS AGAINST BACKGROUND OF DIABETES MELLITUS IN EXPERIMENT

METHOD FOR SIMULATING ATHEROSCLEROSIS AGAINST BACKGROUND OF DIABETES MELLITUS IN EXPERIMENT

机译：试验中糖尿病背景下模拟动脉粥样硬化的方法

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FIELD: experimental medicine. ;SUBSTANCE: invention relates to experimental medicine, namely to pathophysiology and cardiovascular surgery, and can be used to study the mechanisms of occurrence and development of atherosclerotic damage to the cardiovascular system against the background of diabetes mellitus in experimental animals. The method for simulating atherosclerosis against the background of diabetes mellitus in the experiment is that outbred male rabbits are daily taken throughout the experiment, products containing 0.8-1 g of cholesterol per 1 kg of body weight with free access to 5% glucose solution, average calorie content 4000-5000 kcal/day. After 3 weeks from the beginning of the diet, an analysis of the lipid and glycemic profile of the whole blood of rabbits is carried out with the determination of the atherogenic index to ascertain the fact of dyslipidemia, as well as a study of glycosylated hemoglobin. Then dithizone is injected intravenously at a dose of 25 mg/kg. 24 hours after the injection of dithizone, the level of glucose in the capillary blood of rabbits is determined using a glucometer and the glycosylated hemoglobin is re-examined. For 6 months from the start of the experiment, the rabbits continue to receive the indicated diet. The blood glucose level is adjusted by subcutaneous injection of short-acting insulin, maintaining it in the range of 10-12 mmol/l. After 6 months from the beginning of the experiment, the development of atherosclerosis against the background of diabetes mellitus in rabbits was confirmed by the study of blood biochemical parameters, ultrasound Doppler sonography of the arteries of the extremities, morphological examination of the heart and arteries after the animal was removed from the experiment.;EFFECT: invention makes it possible to simulate atherosclerosis against the background of diabetes mellitus. ;1 cl
机译：现场：实验医学。物质：发明涉及实验药物，即对病理生理学和心血管手术，可用于研究对实验动物糖尿病背景的心血管系统发生动脉粥样硬化损伤的发生机制。在实验中模拟动脉粥样硬化的方法是在实验中，每天在整个实验中进行异常雄性兔，含有0.8-1g胆固醇的每1kg体重，可自由获得5％葡萄糖溶液，平均卡路里内容4000-5000千卡/天。从饮食开始3周后，通过测定动脉发生指数来确定血脂血症的动态指数以及糖基化血红蛋白的研究，对兔全血的脂质和血糖概况进行分析。然后以25mg / kg的剂量静脉内注射二硫胺。注射二硫醚后24小时，使用血糖仪测定兔子毛细血管血液中的葡萄糖水平，再检查糖基化血红蛋白。从实验开始时6个月，兔继续接受指示的饮食。通过皮下注射短作用胰岛素来调节血糖水平，将其保持在10-12mmol / L的范围内。从实验开始前6个月后，通过研究血液生化参数的研究证实了对糖尿病患者的糖尿病背景的动脉粥样硬化，超声多普勒超声检查的四肢动脉，心脏和动脉的形态学检查从实验中取出了动物。效果：发明使得可以模拟糖尿病背景的动脉粥样硬化。 ; 1 Cl.

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