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MULTIMERIZING POLYPEPTIDES DERIVED FROM JELLY ROLL FOLD DOMAIN OF ADENOVIRUS PENTON BASE
MULTIMERIZING POLYPEPTIDES DERIVED FROM JELLY ROLL FOLD DOMAIN OF ADENOVIRUS PENTON BASE
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机译：衍生自腺病毒柱底座的果冻辊折叠结构域的多聚多肽
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摘要
The present invention relates to the design and the production of a novel polypeptide scaffolds for optimized presentation of oligopeptides, polypeptide sequences, protein domains, proteins and protein complexes made up of two, several or many subunits. These oligopeptides, polypeptide sequences, protein domains and proteins presented by the polypeptide scaffolds of the invention can include antigenic entities that stimulate the immune system to trigger an immune response, for example for vaccination purposes, or for preparing antibodies or other binder molecules in cell culture, or in vitro in a test tube. In a preferred embodiment, the polypeptides of the invention are assembled into Virus Like Particles (VLPs) optimized for presentation of antigens useful in the context of vaccination against infectious agents or tumors.
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