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首页> 外国专利> METHOD FOR PREDICTING CARDIOVASCULAR COMPLICATIONS WITHIN 12 MONTHS AFTER ELECTIVE ENDOVASCULAR MYOCARDIAL REVASCULARIZATION IN PATIENTS WITH ISCHEMIC HEART DISEASE

METHOD FOR PREDICTING CARDIOVASCULAR COMPLICATIONS WITHIN 12 MONTHS AFTER ELECTIVE ENDOVASCULAR MYOCARDIAL REVASCULARIZATION IN PATIENTS WITH ISCHEMIC HEART DISEASE

机译：在缺血性心脏病患者中预测12个月内12个月内的心血管并发症的方法

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FIELD: medicine.;SUBSTANCE: invention relates to medicine, namely to cardiology, and can be used to predict adverse cardiovascular events within 12 months after planned endovascular myocardial revascularization. The method includes determining the level of endothelin-1 in the blood and the ratio of the waist to the thighs before the planned endovascular myocardial revascularization. Then, the risk of developing adverse cardiovascular events p is calculated using the formula p = 1/1 + exp (-z), where p is the probability of developing cardiovascular complications, exp is the exponent, z is the value of the discriminant function, and the value of the discriminant function is determined by the formula z=ax1+bx2, where x1-x2 are the values of the variables corresponding to the indicators under consideration, the coefficients a, b are the weight coefficients of the corresponding indicators, x1 is the concentration of endothelin-1, x1 = 1 - if the concentration of endothelin-1 is greater than 0.75, x1 = 2 - if the concentration of endothelin-1 is less than or equal to 0.751, a = 4.591 is a constant, x2 is the ratio of the waist to the thighs, x2 = 1 - if the ratio of the waist to the thighs is less than or equal to 1.0495, x2 = 2 - if the ratio of the waist to the thighs is greater than 1.0495, b = -2.006 is a constant. If p is less than 0.995, the development of cardiovascular complications is predicted. ;EFFECT: use of the invention makes it possible to predict the onset of unfavorable cardiovascular events within 12 months after planned endovascular myocardial revascularization, to obtain an individual risk profile of a particular patient with coronary heart disease with low invasiveness and a high level of sensitivity - 88% and specificity - 92%.;1 cl, 1 dwg, 3 tbl, 2 ex
机译：田地：医学。物质：发明涉及药物，即心脏病学，并且可用于在计划血管内心肌血管内血管内血管内血管内发生后12个月内预测不良心血管事件。该方法包括在计划血管内心肌血运重建之前确定血液中的内皮素-1的水平和腰部与大腿的比率。然后，使用公式P = 1/1 + exp（-Z）计算发育不良心血管事件P的风险，其中P是发育心血管并发症的概率，EXP是指数，Z是判别函数的值，并且判别函数的值由公式z = ax 1 + bx 2 确定，其中x 1 -x 2 是与所考虑的指示器对应的变量的值，系数a，b是相应指标的权重系数，x 1 是内皮素-1，x的浓度 1 = 1 - 如果内皮素-1的浓度大于0.75，则x 1 = 2 - 如果内皮素-1的浓度小于或等于0.751， a = 4.591是常数，x 2 是腰部到大腿的比率，x 2 = 1 - 如果腰部与大腿的比例小于或等于1.0495，x 2 = 2 - 如果腰部的比率为大腿大于1.0495，B = -2.006是恒定的。如果p小于0.995，则预测心血管并发症的发展。 ;效果：使用本发明使得可以预测计划血管内心肌血管内血运重建后12个月内的不利心血管事件发生，以获得具有低侵入性和高水平敏感性冠心病的特定患者的个体风险概况和高水平的敏感性 - 88％和特异性 - 92％; 1 cl，1 dwg，3 tbl，2前

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