首页> 外国专利> MODULATION OF UBIQUITIN CARBOXY-TERMINAL HYDROLASE LIGASE 1 EXPRESSION

MODULATION OF UBIQUITIN CARBOXY-TERMINAL HYDROLASE LIGASE 1 EXPRESSION

机译:泛素羧酸末端水解酶连接酶1表达的调节

摘要

Disclosed are compositions and methods for treating neurological diseases, disorders, and injuries in a subject in need thereof. Particularly disclosed are compositions and methods for treating neurological diseases, disorders, and injuries that are associated with upper motor neurons in a subject in need thereof in which methods expression of ubiquitin carboxyl hydrolase ligase 1 (UCHL1) is modulated in the subject, for example, via gene therapy being administered to the subject in order to express UCHL1 in upper motor neurons of the subject.
机译:公开了用于治疗有需要的受试者的神经疾病,病症和损伤的组合物和方法。特别公开的是用于治疗与有此需要的受试者的上部运动神经元相关的神经疾病,疾病和损伤的组合物和方法,其中在该受试者中调节遍税羧酸水解酶连接酶1(UCHL1)的方法,通过基因治疗被施用于受试者,以表达对象的上电机神经元中的UCHL1。

著录项

  • 公开/公告号WO2021119622A1

    专利类型

  • 公开/公告日2021-06-17

    原文格式PDF

  • 申请/专利权人 NORTHWESTERN UNIVERSITY;

    申请/专利号WO2020US64939

  • 申请日2020-12-14

  • 分类号C12N9/48;C12N15/57;C12N15/861;A61K48;A61P25/28;

  • 国家 US

  • 入库时间 2022-08-24 19:26:36

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