首页> 外国专利> NOVEL DIHYDROINDENO1,2-CPYRAZOLE-3-CARBOXAMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF NEURODEVELOPMENTAL DISORDERS OR NEURODEGENERATIVE DISEASES, COMPRISING SAME

NOVEL DIHYDROINDENO1,2-CPYRAZOLE-3-CARBOXAMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF NEURODEVELOPMENTAL DISORDERS OR NEURODEGENERATIVE DISEASES, COMPRISING SAME

机译：新型二氢吲哚[1,2-C]吡唑-3-甲酰胺衍生物和用于预防或治疗神经发育障碍或神经变性疾病的药物组合物，包括相同

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摘要

The present invention relates to a novel dihydroindeno[1,2-c]pyrazole-3-carboxamide derivative and a pharmaceutical composition for the prevention or treatment of neurodevelopmental disorders or neurodegenerative diseases, the pharmaceutical composition comprising same as an active ingredient. The present invention can provide a compound which has excellent GSK3β inhibitory activity and excellent efficacy of inhibiting NFκB activity and activating the Wnt/β-catenin signaling pathway in MeCP2-depleted cells, and thus is effective as a composition for the prevention or treatment of neurodevelopmental disorders or neurodegenerative diseases.

机译：本发明涉及新型二氢吲唑-3-甲酰胺衍生物和用于预防或治疗神经发育疾病或神经变性疾病的药物组合物，该药物组合物包含与活性成分相同的药物组合物。本发明可以提供一种具有优异的GSK3β抑制活性的化合物，抑制NFκB活性的优异功效并激活MeCP2耗尽细胞中的Wnt /β-连环蛋白信号通路，因此作为预防或治疗神经发育的组合物是有效的疾病或神经变性疾病。

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公开/公告号WO2021133129A2

专利类型
公开/公告日2021-07-01

原文格式PDF
申请/专利权人 KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY;UNDBIO CO. LTD.;
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申请/专利号WO2020KR19164
发明设计人 CHO HEE YEONG;NAM HYE JIN;YOON SAE BOM;KOH BYUM SEOK;JUN YONG SOO;KWON HYUK JIN;JEONG DAE YOUNG;LIM HEE JONG;MOON BYOUNG SAN;PARK WOO KYU;KIM HYEON YOUNG;LEE YU NO;
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申请日2020-12-24
分类号C07D231/54;
国家 KR
入库时间 2022-08-24 19:52:26

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