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POROUS COLLAGEN/POLYMER MATRIX BIOCOMPOSITE MATERIAL AND USE THEREOF AS AN IMPLANT FOR REPAIRING MENISCAL LESIONS OF THE KNEE AND/OR FOR PREVENTING OR TREATING OSTEOARTHRITIS OF THE KNEE
POROUS COLLAGEN/POLYMER MATRIX BIOCOMPOSITE MATERIAL AND USE THEREOF AS AN IMPLANT FOR REPAIRING MENISCAL LESIONS OF THE KNEE AND/OR FOR PREVENTING OR TREATING OSTEOARTHRITIS OF THE KNEE
The invention concerns a porous biocomposite material comprising a polymer matrix having pores defined by a plurality of surfaces and collagen which totally or partially covers the surfaces of the pores and the outer surfaces of the polymer matrix, the weight ratio of collagen to the polymer matrix being from 20/80 to 40/60. The polymer matrix of the porous biocomposite material comprises a copolymer which is prepared from a poly(ε-caprolactone) diol, a poly(lactide-co-glycolide) diol and a lysine diisocyanate (LDI). The invention also concerns an implant which is porous, biodegradable foam, with biomechanics close to the normal meniscus, with tensile strength, pressure resistance and tear strength, and preventing the pores from collapsing under the condyle-tibia pressure. It serves as a scaffolding for the repair or replacement of the destroyed meniscus, indicated in grade 3 or 4 terminal osteoarthritis of the knee, for preventing or treating advanced osteoarthritis of the knee by cartilage regeneration, in order to avoid knee replacement in young patients. The implant of the present invention is biocompatible as well as the degradation products. The invention also proposes a method for producing these biocompatible implants.
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