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GENE EXPRESSION SWITCH BASED ON RED LIGHT AND FAR-RED LIGHT REGULATION, AND CONSTRUCTION METHOD AND APPLICATION THEREOF
GENE EXPRESSION SWITCH BASED ON RED LIGHT AND FAR-RED LIGHT REGULATION, AND CONSTRUCTION METHOD AND APPLICATION THEREOF
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机译:基于红光和远红光调节的基因表达式开关,以及其施工方法及其应用
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摘要
Provided are a gene expression switch/system (REDMAP system) based on red light and far-red light regulation for mammalian cells, comprising a photoreceptor and an effector. The REDMAP system has the capabilities of simple design, small modules, high-efficiency induction, and rapid and sensitive transcription expression regulation. The REDMAP system can efficiently and accurately regulate transgenic expression of mammalian cells and a signaling pathway based on protein-protein interaction by means of red light and far-red light, and has the characteristics of non-toxicity, high efficiency, spatio-temporal specificity, reversible induction of gene expression and the like. The REDMAP system can accurately regulate expression of a target gene in vivo, facilitates long-term drug delivery of adeno-associated viruses (AAV), can be used for regulating insulin expression, can be used for various biological and pre-transformation application research, such as regulation of a cell signaling pathway, epigenetic engineering, and cell therapy based on drug delivery, and has potential application value in the fields of basic biological research, mammalian gene engineering, and regenerative medicine.
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