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HIGH-EFFICIENCY LOW-TOXICITY ANTI-CANCER COMPOUND SYNTHESIZED BY AUTOCATALYSIS IN CELLS AND LIVING BODIES AND SYNTHESIS METHOD FOR ANTI-CANCER COMPOUND
HIGH-EFFICIENCY LOW-TOXICITY ANTI-CANCER COMPOUND SYNTHESIZED BY AUTOCATALYSIS IN CELLS AND LIVING BODIES AND SYNTHESIS METHOD FOR ANTI-CANCER COMPOUND
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机译：通过细胞和生物体的自催化合成的高效低毒性抗癌化合物和抗癌化合物的合成方法合成
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摘要
Disclosed is a high-efficiency low-toxicity anti-cancer compound synthesized by autocatalysis in cells and living bodies. The anti-cancer compound is prepared by means of chemical synthesis of a metal complex precursor and an organic active molecule precursor outside the cells or synthesis of the metal complex precursor and the organic active molecule precursor in the cells by means of a bioorthogonal reaction. The metal complex is a platinum, ruthenium, iridium or osmium metal complex, and the organic active molecule means small organic molecules having certain biological activities, for example, the small organic molecules having biological activities such as anti-inflammation, anti-bacteria, anti-angiogenesis, and anti-cancer. The organic active molecule precursor is an organic active molecule subjected to chemical modification, and the organic active molecule is one of rhein acid, oleanolic acid, ursolic acid, naphthalimide, cumarin acid, anthracene-9-carboxylic acid or indometacin. Also disclosed is a synthesis method for the anti-cancer compound. The anti-cancer compound in the present invention shows a good anti-tumor effect by being synthesized by means of either an extracellular reaction or an intracellular reaction.
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